|
Insulin measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.
|
23263489 |
2013 |
|
Insulin measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
|
21873549 |
2011 |
|
Insulin measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
|
21873549 |
2011 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Lean body mass
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.
|
30593698 |
2019 |
|
Fasting blood glucose measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
|
23903356 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 × 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 × 10(-7)).
|
25784503 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, PCSK1 rs6235 risk allele was related to Adv36 seropositivity (chi(2)=6.85, p=0.033) in overweight/obese subgroup.
|
26680480 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data revealed no association of PCSK1 rs6235 with the risk of obesity or overweight in the complete subjects.
|
24140494 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
No difference was found in the association with different obesity grades, and no association of PCSK1 rs6234-rs6235</span> with obesity was identified in Asian populations.
|
25355447 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that common PCSK1 variants (notably rs6232 and rs6235) contribute modestly to obesity in multi-ethnic American population.
|
23451278 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the association of the PCSK1 single-nucleotide polymorphism (SNP) rs6235 (encoding an S690T substitution) with essential hypertension (EH), obesity and related traits in the Han Chinese population.
|
22592666 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group.
|
22737226 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity.
|
20534142 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our data suggest that the PCSK1 rs6232 and rs6235 SNPs are not major contributors to common obesity in the general population.
|
19528091 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 x 10(-8) and P = 2.31 x 10(-12), respectively).
|
18604207 |
2008 |
|
Overweight or obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study was intended to investigate the association between the PCSK1 rs6235 SNP and the prevalence of overweight or obesity, or obesity-related metabolic traits in a Taiwanese population.
|
24140494 |
2014 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, the rs6235 SNP was significantly associated with hypertension (OR=1.26, 95% CI (1.10-1.46), P=0.001); the odds ratios of GC vs GG and CC vs GG were 1.30 (95% CI (1.06-1.58), P=0.010) and 1.55 (95% CI (1.12-2.13), P=0.007), respectively.
|
22592666 |
2012 |
|
Essential Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the PCSK1 SNP rs6235 was associated with EH and blood pressure in the Han Chinese population, and this association may be mediated by the SNP's effect on RAA levels. rs6235 was also associated with BMI in this population.
|
22592666 |
2012 |