Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Then, two-way analysis of covariance (ANCOVA) was applied to investigate main effects and interactions of PD and DRD3 Ser9Gly polymorphism on the brain function via amplitude of low-frequency fluctuations (ALFF) approach.
|
31143436 |
2019 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that behavioral addictions in PD are associated with an early onset of the disease, the rs6280 DRD3 SNV and the type of dopamine agonist.
|
29361389 |
2018 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Twenty-eight patients with PD were genotyped for known functional polymorphisms in DRD2 (rs6277 and rs1800497) and DRD3 (rs6280) receptors.
|
29856137 |
2018 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of the DRD2 CA<sub>n</sub>-STR and DRD3 Ser9Gly polymorphisms with Parkinson's disease and response to dopamine agonists.
|
27817855 |
2017 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results of this meta-analysis suggest that the Ser9Gly SNP is not associated with schizophrenia.
|
29200860 |
2017 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Remarkably, alleles of <i>COMT</i> rs165774 (G), <i>DRD2</i> rs6277 (T), and <i>DRD3</i> rs6280 (C) were associated with raised predisposition to schizophrenia (all <i>P</i><0.001).
|
29255361 |
2017 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson's disease patients.
|
27325396 |
2016 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the relationship between cognitive function, a proposed schizophrenia endophenotype, and two genetic polymorphisms related to dopamine function, catechol-O-methyl transferase (COMT) Val158Met and dopamine receptor 3 (DRD3) Ser9Gly.
|
26376054 |
2016 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The DRD3 (rs6280) polymorphism, but not DRD2 (Taq1A) or GRIN2B, influences younger PD age of onset in the US Caucasian population.
|
26627941 |
2016 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this sample, we found a possible interaction between the BDNF Val66Met and DRD3 Ser9Gly SNPs in increasing the risk of suicide attempt(s) in our SCZ sample.
|
25264289 |
2015 |
Drug-induced tardive dyskinesia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis comprising 1291 East Asian subjects also showed no association between the polymorphism and TD; the Mantel-Haenszel pooled OR for TD among carriers of the DRD3 Ser9Gly of the eight Asian studies was 0.94 (95% CI: 0.78-1.12).
|
22172931 |
2012 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In our Japanese case-control sample (43 with TD/157 without TD), we found no association between the DRD3 Ser9Gly polymorphism in schizophrenia and TD (genotype: p=0.92; allele: p=1.00).
|
22172931 |
2012 |
Tardive Dyskinesia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis comprising 1291 East Asian subjects also showed no association between the polymorphism and TD; the Mantel-Haenszel pooled OR for TD among carriers of the DRD3 Ser9Gly of the eight Asian studies was 0.94 (95% CI: 0.78-1.12).
|
22172931 |
2012 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of diphasic dyskinesia (DDSK) was exclusively associated with the DRD3 p.S9G variant after adjusting for gender, age at PD onset, Hoehn & Yahr stage, and duration of levodopa treatment.
|
20945430 |
2011 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among white Hispanics who carried two alleles, the Ser9Gly DRD3 (rs6280) polymorphism was associated with a decreased risk of PD (OR=0.4, 95% CI 0.2-0.8).
|
21663922 |
2011 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Consequently, we observed that the genotypic distribution of rs6280 was nominally associated with SZ (P = 0.045), with the ancestral CC genotype being significantly over-represented in SZ patients.
|
21595009 |
2011 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on allele and genotype frequencies in both groups, we found no significant association of DRD3 Ser9Gly polymorphisms and COMT (rs165656) with schizophrenia in Malays.
|
21948748 |
2011 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the association between dopaminergic polymorphisms [DRD2 -141C Ins/Del, DRD3 Ser9Gly, and SLC6A3 VNTR] and schizophrenia.
|
19766158 |
2010 |
Tardive Dyskinesia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that there is no or little association between DRD3 rs6280 polymorphisms and prevalence of TD.
|
19358223 |
2010 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype.
|
20434388 |
2010 |
Drug-induced tardive dyskinesia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that there is no or little association between DRD3 rs6280 polymorphisms and prevalence of TD.
|
19358223 |
2010 |
Drug-induced tardive dyskinesia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, a number of studies have focused on the association of dopamine system gene polymorphisms and TD, with the most consistent findings being an association between TD and the Ser9Gly polymorphism of the DRD3 gene and the TaqIA site 3' of the DRD2 gene.
|
19238168 |
2009 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
As recent observations indicate the dopamine D(3) receptor (DRD3) to modulate both therapeutic action of levodopa and dyskinesia, we reappraised the impact of the DRD3 Ser9Gly polymorphism on development of motor complications in a large scale association study based on the gene bank of the German Competence Network on Parkinson's disease.
|
19353703 |
2009 |
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of ICRB in PD.
|
19562769 |
2009 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether the efficacy of aripiprazole can be predicted by a functional DRD3 gene polymorphism Ser9Gly (rs6280) as modified by clinical factors in Han Chinese hospitalized patients with acutely exacerbated schizophrenia.
|
19302829 |
2009 |