Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PECAM1 P16284 platelet and endothelial cell adhesion molecule 1 Cell adhesion 0.426 0.846 8
EPHX2 P34913 epoxide hydrolase 2 Enzyme 1.8E-21 0.568 0.654 7
SMAD6 O43541 SMAD family member 6 Transcription factor 3.6E-20 0.579 0.731 3
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885 21
CYP1A1 P04798 cytochrome P450 family 1 subfamily A member 1 Enzyme 1.1E-17 0.436 0.846 14
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
HAS1 Q92839 hyaluronan synthase 1 1.3E-12 0.670 0.577 2
MFN1 Q8IWA4 mitofusin 1 Enzyme 2.5E-10 0.644 0.577 10
PTGIS Q16647 prostaglandin I2 synthase 1.2E-09 0.617 0.654 2
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923 25
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 10
TNC P24821 tenascin C 1.3E-07 0.433 0.846 10
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885 14
CYBA P13498 cytochrome b-245 alpha chain 8.9E-06 0.520 0.769 10
NPPB P16860 natriuretic peptide B 9.9E-06 0.513 0.808 20
SLC2A4 P14672 solute carrier family 2 member 4 Transporter 4.7E-05 0.528 0.769 3
SMAD9 O15198 SMAD family member 9 Transcription factor 6.4E-05 0.666 0.308 1
CLU P10909 clusterin 7.8E-05 0.426 0.885 14
TACR2 P21452 tachykinin receptor 2 G-protein coupled receptor 8.8E-05 0.700 0.500 3
PDE5A O76074 phosphodiesterase 5A 1.1E-04 0.513 0.731 14
GPR182 O15218 G protein-coupled receptor 182 G-protein coupled receptor 1.4E-04 0.691 0.462 1