Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 82 6
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 81 2
TAC1 P20366 tachykinin precursor 1 0.75 0.424 0.923 77 0
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 59 47
S100B P04271 S100 calcium binding protein B Calcium-binding protein 4.4E-02 0.383 0.923 44 0
PRNP F7VJQ1 P04156 prion protein 6.3E-04 0.445 0.923 43 30
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 33 19
HSP90AA1 P07900 heat shock protein 90 alpha family class A member 1 Chaperone 0.86 0.411 0.923 15 0
HPGDS O60760 hematopoietic prostaglandin D synthase 1.8E-06 0.388 0.923 11 5
HSPA4 P34932 heat shock protein family A (Hsp70) member 4 1.00 0.394 0.923 7 7
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 110 65
PRL P01236 prolactin Signaling 2.9E-07 0.406 0.885 97 0
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885 93 2
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 89 1
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 62 2