Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL6 P05231 interleukin 6 0.32 0.248 0.962 8
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 8
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 7
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 7
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 6
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 6
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 4
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 2
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 2
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962 2
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 2
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 15
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 10
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 10
S100B P04271 S100 calcium binding protein B Calcium-binding protein 4.4E-02 0.383 0.923 8
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 7
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 6
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 5
TAC1 P20366 tachykinin precursor 1 0.75 0.424 0.923 5
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 4
GSTT1 P30711 glutathione S-transferase theta 1 1.5E-04 0.393 0.923 4
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 4
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 3