Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 27
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 86
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 51
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 32
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 39
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 37
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 21