Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1083 13
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 816 119
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 747 2600
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 656 3066
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 679 23
LMNA P02545 lamin A/C 1.00 0.384 0.885 824 285
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 702 98
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 654 55
TWIST1 Q15672 twist family bHLH transcription factor 1 Transcription factor 0.34 0.397 0.846 559 31
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 622 47
COX8A P10176 cytochrome c oxidase subunit 8A Enzyme 0.12 0.400 0.846 526 2