Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IGFBP3 P17936 insulin like growth factor binding protein 3 Enzyme modulator 0.91 0.439 0.808 43
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 41
IL12B P29460 interleukin 12B Signaling 1.1E-04 0.480 0.885 28
LGALS3 P17931 galectin 3 Signaling 2.3E-05 0.392 0.846 26
NOD2 Q9HC29 nucleotide binding oligomerization domain containing 2 Enzyme 2.0E-30 0.423 0.923 25
DPP4 P27487 dipeptidyl peptidase 4 Enzyme 7.3E-09 0.420 0.808 24
CX3CL1 P78423 C-X3-C motif chemokine ligand 1 Signaling 0.61 0.478 0.808 23
DEFB4A O15263 defensin beta 4A 1.2E-03 0.507 0.769 22
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885 21
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 21
CFTR P13569 CF transmembrane conductance regulator Ion channel 2.2E-58 0.424 0.885 21
F2R P25116 coagulation factor II thrombin receptor G-protein coupled receptor 8.5E-03 0.444 0.846 21
MAPK8 P45983 mitogen-activated protein kinase 8 Kinase 1.00 0.397 0.885 21
S100A9 P06702 S100 calcium binding protein A9 Calcium-binding protein 0.48 0.433 0.885 21
PLAT P00750 plasminogen activator, tissue type Enzyme 5.7E-05 0.445 0.885 19
SLC11A1 P49279 solute carrier family 11 member 1 Transporter 1.5E-19 0.525 0.846 19
GZMB P10144 granzyme B Enzyme 3.7E-14 0.453 0.808 18
S100A8 P05109 S100 calcium binding protein A8 Calcium-binding protein 0.14 0.430 0.962 18
CLDN1 O95832 claudin 1 Cell-cell junction 1.0E-03 0.481 0.808 17
IL23A Q9NPF7 interleukin 23 subunit alpha Signaling 0.36 0.415 0.846 17
MUC2 Q02817 mucin 2, oligomeric mucus/gel-forming Enzyme modulator 9.4E-10 0.486 0.808 17
NFKBIA P25963 NFKB inhibitor alpha 0.99 0.487 0.885 17
PROC P04070 protein C, inactivator of coagulation factors Va and VIIIa Enzyme 1.9E-05 0.504 0.808 17
EGR1 P18146 early growth response 1 Nucleic acid binding 0.35 0.433 0.923 16