Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 84
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 72
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 65
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 62
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 59
GSTT1 P30711 glutathione S-transferase theta 1 1.5E-04 0.393 0.923 55
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 53
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 52
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 52
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 52
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 49
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885 48
HLA-G P17693 major histocompatibility complex, class I, G 1.4E-11 0.461 0.769 46
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 45