Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
NR1H4 Q96RI1 nuclear receptor subfamily 1 group H member 4 Nuclear receptor 9.4E-04 0.513 0.808 21
A2M P01023 alpha-2-macroglobulin Enzyme modulator 4.5E-11 0.529 0.769 20
ABCC3 O15438 ATP binding cassette subfamily C member 3 Transporter 1.2E-26 0.517 0.769 20
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 20
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 20
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 18
PCNA P12004 proliferating cell nuclear antigen Nucleic acid binding 0.98 0.382 0.846 17
PPARA Q07869 peroxisome proliferator activated receptor alpha Nuclear receptor 3.0E-02 0.432 0.885 17
TXNIP Q9H3M7 thioredoxin interacting protein 0.16 0.490 0.731 17
IL6ST P40189 interleukin 6 signal transducer Signaling 1.00 0.475 0.808 16
AKR1B1 P15121 aldo-keto reductase family 1 member B Enzyme 2.0E-05 0.491 0.885 15
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 15
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 15
PTK2 Q05397 protein tyrosine kinase 2 Kinase 1.00 0.497 0.808 15
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 14
CTSL P07711 cathepsin L Enzyme 8.0E-03 0.488 0.846 14
ENG P17813 endoglin 1.00 0.446 0.846 14
HNF1A P20823 HNF1 homeobox A Nucleic acid binding 0.96 0.478 0.846 14
TGFA P01135 transforming growth factor alpha Signaling 0.72 0.432 0.885 14
DNMT3B Q9UBC3 DNA methyltransferase 3 beta 0.20 0.453 0.846 13
HPRT1 P00492 hypoxanthine phosphoribosyltransferase 1 Enzyme 0.94 0.500 0.808 13
TFRC P02786 transferrin receptor Enzyme 7.0E-05 0.437 0.885 13
ABCA1 O95477 ATP binding cassette subfamily A member 1 Transporter 1.5E-13 0.467 0.846 12
COL18A1 P39060 collagen type XVIII alpha 1 chain 1.7E-10 0.449 0.808 12