Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 138
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 75
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 59
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 47
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 38
XDH P47989 xanthine dehydrogenase Enzyme 2.6E-22 0.529 0.846 38
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 35
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 34
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 34
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 34
G6PD P11413 glucose-6-phosphate dehydrogenase Enzyme 0.97 0.424 0.846 32
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 30
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 28
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 27
GJB2 P29033 gap junction protein beta 2 Cell-cell junction 6.6E-16 0.441 0.846 25
HAMP P81172 hepcidin antimicrobial peptide 8.2E-03 0.433 0.846 24
CTSB P07858 cathepsin B Enzyme 5.9E-11 0.457 0.846 22
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846 22
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 21
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 21