Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
GSR P00390 glutathione-disulfide reductase Enzyme 1.3E-06 0.494 0.846 31
MFN2 O95140 mitofusin 2 Enzyme 0.99 0.471 0.846 29
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 27
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 27
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 26
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 26
CCN2 P29279 cellular communication network factor 2 Signaling 5.0E-04 0.399 0.846 26
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26
MIF P14174 macrophage migration inhibitory factor 1.2E-02 0.412 0.885 26
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 26
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
HAMP P81172 hepcidin antimicrobial peptide 8.2E-03 0.433 0.846 24
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 23
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
S100B P04271 S100 calcium binding protein B Calcium-binding protein 4.4E-02 0.383 0.923 23
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 23
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 22
CTSB P07858 cathepsin B Enzyme 5.9E-11 0.457 0.846 22
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 22
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808 21
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885 21
ADRB2 P07550 adrenoceptor beta 2 G-protein coupled receptor 0.53 0.442 0.923 20
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 20
NPPB P16860 natriuretic peptide B 9.9E-06 0.513 0.808 20