Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 2
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 40
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 27
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 21
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 6
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 8
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 18
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 8
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 28
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 19
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 2
IL2 P60568 interleukin 2 0.48 0.336 0.885 8
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 5
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 34
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 25
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 20
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 11
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35