Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 60 79
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 60 28
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 58 9
GPX1 P07203 glutathione peroxidase 1 Enzyme 3.9E-05 0.458 0.923 58 1
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 57 9
PAX6 P26367 paired box 6 1.00 0.450 0.769 55 109
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 54 21
BCL2L1 Q07817 BCL2 like 1 Signaling 0.94 0.493 0.885 53 4
CYP1A2 P05177 cytochrome P450 family 1 subfamily A member 2 Enzyme 2.5E-10 0.494 0.923 52 1
KCNJ11 Q14654 potassium inwardly rectifying channel subfamily J member 11 Ion channel 1.1E-02 0.529 0.615 50 65
GNB3 P16520 G protein subunit beta 3 Enzyme 3.3E-11 0.518 0.808 49 4
OGG1 O15527 8-oxoguanine DNA glycosylase 3.9E-12 0.453 0.808 45 2
GCG P01275 glucagon 3.5E-02 0.431 0.885 43 0
CCND2 P30279 cyclin D2 Enzyme modulator 0.99 0.477 0.808 42 12
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 41 27
KL Q9UEF7 klotho Enzyme 2.2E-04 0.448 0.769 38 4
SNAP25 P60880 synaptosome associated protein 25 Transporter 0.99 0.489 0.808 36 2
ATP2A2 P16615 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Transporter 1.00 0.529 0.808 34 16
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 33 19
HBA1 P69905 hemoglobin subunit alpha 1 6.7E-03 0.508 0.808 33 17
ADCY5 O95622 adenylate cyclase 5 1.00 0.617 0.577 31 23
EDNRB P24530 endothelin receptor type B G-protein coupled receptor 9.2E-03 0.470 0.846 31 15
PAM P19021 peptidylglycine alpha-amidating monooxygenase Enzyme 6.9E-06 0.542 0.692 30 22
ATF3 P18847 activating transcription factor 3 Transcription factor 8.9E-02 0.494 0.885 30 1