Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 184 9
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
INS P01308 insulin 0.30 0.445 0.923 157 34
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 147 48
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 115 90
LEP P41159 leptin 0.46 0.349 0.846 114 3
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 113 9
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 110 65
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 94 70
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 89 1
LEPR P48357 leptin receptor Signaling 0.99 0.433 0.808 79 29
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 72 6
PPARA Q07869 peroxisome proliferator activated receptor alpha Nuclear receptor 3.0E-02 0.432 0.885 67 6
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 66 38
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 66 6
RELA Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 1.00 0.406 0.885 63 3
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 62 2