Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 95 596
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 93 98
HTR1A P08908 5-hydroxytryptamine receptor 1A G-protein coupled receptor 0.20 0.522 0.846 93 1
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 92 30
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 91 10
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 90 28
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 83 37
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 72 928
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 69 3
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885 69 0
TYMS P04818 thymidylate synthetase Enzyme 0.72 0.425 0.846 67 4
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885 64 4
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 60 28
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 59 47
APOA1 P02647 apolipoprotein A1 5.5E-04 0.429 0.885 59 21
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 58 15
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 58 9
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 57 16
ENO1 P06733 enolase 1 Enzyme 1.9E-05 0.481 0.885 57 0
PAX6 P26367 paired box 6 1.00 0.450 0.769 55 109
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 54 17
BCL2L1 Q07817 BCL2 like 1 Signaling 0.94 0.493 0.885 53 4
ADRB2 P07550 adrenoceptor beta 2 G-protein coupled receptor 0.53 0.442 0.923 53 1