Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 16
MAP1LC3A Q9H492 microtubule associated protein 1 light chain 3 alpha Cellular structure 2.8E-02 0.610 0.654 15
PLAT P00750 plasminogen activator, tissue type Enzyme 5.7E-05 0.445 0.885 15
SLC9A1 P19634 solute carrier family 9 member A1 Transporter 0.79 0.550 0.731 15
FADD Q13158 Fas associated via death domain 0.53 0.537 0.846 14
HCN1 O60741 hyperpolarization activated cyclic nucleotide gated potassium channel 1 1.00 0.564 0.654 14
GHR P10912 growth hormone receptor Signaling 8.4E-05 0.490 0.846 12
NTRK1 P04629 neurotrophic receptor tyrosine kinase 1 Kinase 2.0E-06 0.422 0.808 12
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 12
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846 11
MBP P02686 myelin basic protein 0.28 0.510 0.885 11
AIFM1 O95831 apoptosis inducing factor mitochondria associated 1 Enzyme 1.00 0.527 0.769 10
CXCR3 P49682 C-X-C motif chemokine receptor 3 G-protein coupled receptor 0.18 0.436 0.808 10
GRIN2A Q12879 glutamate ionotropic receptor NMDA type subunit 2A Ion channel 1.00 0.522 0.808 10
CLOCK O15516 clock circadian regulator 1.00 0.463 0.885 9
MAP2 P11137 microtubule associated protein 2 1.00 0.537 0.692 9
CASP1 P29466 caspase 1 Enzyme 3.5E-05 0.413 0.885 8
CCR2 P41597 C-C motif chemokine receptor 2 2.3E-02 0.418 0.846 8
GRIN1 Q05586 glutamate ionotropic receptor NMDA type subunit 1 Ion channel 0.98 0.561 0.692 8
IGFBP3 P17936 insulin like growth factor binding protein 3 Enzyme modulator 0.91 0.439 0.808 8
IREB2 P48200 iron responsive element binding protein 2 Enzyme 1.00 0.619 0.577 8
CAST P20810 calpastatin 4.1E-12 0.541 0.846 7
EIF2S1 P05198 eukaryotic translation initiation factor 2 subunit alpha Nucleic acid binding 0.97 0.587 0.692 7
MAP3K5 Q99683 mitogen-activated protein kinase kinase kinase 5 Kinase 0.52 0.513 0.808 7