Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP8 P22894 matrix metallopeptidase 8 Enzyme 1.1E-24 0.488 0.808 2
PPP1CC P36873 protein phosphatase 1 catalytic subunit gamma Enzyme 0.96 0.861 0.154 2
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 19
OPA1 O60313 OPA1 mitochondrial dynamin like GTPase Enzyme modulator 0.99 0.510 0.846 14
BIRC5 O15392 baculoviral IAP repeat containing 5 Enzyme modulator 5.6E-02 0.495 0.731 13
TIMP2 P16035 TIMP metallopeptidase inhibitor 2 Enzyme modulator 0.79 0.425 0.846 10
TIMP4 Q99727 TIMP metallopeptidase inhibitor 4 Enzyme modulator 3.8E-04 0.559 0.769 7
ARRB1 P49407 arrestin beta 1 Enzyme modulator 0.99 0.588 0.846 5
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962 3
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 18
SIRT3 Q9NTG7 sirtuin 3 Epigenetic regulator 1.6E-04 0.488 0.731 9
ACAN P16112 aggrecan Extracellular structure 1.00 0.528 0.846 7
CX3CR1 P49238 C-X3-C motif chemokine receptor 1 G-protein coupled receptor 6.1E-02 0.457 0.885 26
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 26
AGTR2 P50052 angiotensin II receptor type 2 G-protein coupled receptor 8.2E-03 0.496 0.808 22
ADRB2 P07550 adrenoceptor beta 2 G-protein coupled receptor 0.53 0.442 0.923 20
HTR2A P28223 5-hydroxytryptamine receptor 2A G-protein coupled receptor 0.51 0.473 0.846 17
ADRB1 P08588 adrenoceptor beta 1 G-protein coupled receptor 2.9E-06 0.555 0.769 16
MAS1 P04201 MAS1 proto-oncogene, G protein-coupled receptor G-protein coupled receptor 8.3E-05 0.533 0.769 9
ADRB3 P13945 adrenoceptor beta 3 G-protein coupled receptor 2.5E-07 0.533 0.731 6
HTR2B P41595 5-hydroxytryptamine receptor 2B G-protein coupled receptor 2.7E-10 0.647 0.538 5
CHRM4 P08173 cholinergic receptor muscarinic 4 G-protein coupled receptor 0.97 0.821 0.231 2