Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 184 9
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 147 48
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 146 14
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 133 7
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885 115 6
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 115 1
LEP P41159 leptin 0.46 0.349 0.846 114 3
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 110 1
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
OPRM1 P35372 opioid receptor mu 1 G-protein coupled receptor 7.9E-11 0.457 0.808 109 4