Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1456 27
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1394 183
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 996 23
LEP P41159 leptin 0.46 0.349 0.846 931 15
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 873 39
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 859 12
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 854 163
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 852 81
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 823 34
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64