Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1679 21
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1483 15
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1394 183
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 1368 68
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
ALB P02768 albumin Transporter 0.64 0.317 0.962 1198 21
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1101 185
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
SMUG1 Q53HV7 single-strand-selective monofunctional uracil-DNA glycosylase 1 4.5E-04 0.322 0.923 1034 6
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 1011 8
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 1002 19
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
LEP P41159 leptin 0.46 0.349 0.846 931 15
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 854 163