Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 184 9
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 115 90
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 115 30
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 112 15
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 108 72
FOS P01100 Fos proto-oncogene, AP-1 transcription factor subunit Transcription factor 0.26 0.411 0.885 104 0
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18