Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1679 21
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1483 15
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1394 183
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 1028 7
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 1018 185
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 933 59
LEP P41159 leptin 0.46 0.349 0.846 931 15
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 877 101
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 852 81
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 765 43
CXCR4 P61073 C-X-C motif chemokine receptor 4 G-protein coupled receptor 1.8E-02 0.362 0.923 739 23
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 706 308
MTCO2P12 MT-CO2 pseudogene 12 0.368 0.962 703 0
IFNA1 P01562 interferon alpha 1 0.371 0.923 662 6