Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2245 232
IL6 P05231 interleukin 6 0.32 0.248 0.962 2132 21
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1737 58
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1308 143
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1277 41
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1214 67
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 1173 9
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1105 16
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1087 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1077 12
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 999 26
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 990 7
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 983 56
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 839 55
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 748 8
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846 669 28
CD44 P16070 CD44 molecule (Indian blood group) 2.4E-07 0.363 0.962 664 32
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923 652 15
EPHB2 P29323 EPH receptor B2 Kinase 1.00 0.374 0.846 636 9
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 627 41
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 581 22
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885 561 21
EPO P01588 erythropoietin 1.1E-02 0.381 0.885 560 4
MUC1 P15941 mucin 1, cell surface associated 1.9E-02 0.384 0.885 552 18