Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 88
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
LEP P41159 leptin 0.46 0.349 0.846 78
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 71
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 66
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 59
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 58
TNFSF10 P50591 TNF superfamily member 10 Signaling 0.13 0.413 0.885 54
CXCL12 P48061 C-X-C motif chemokine ligand 12 0.12 0.379 0.846 53
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 51
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 49
CXCR4 P61073 C-X-C motif chemokine receptor 4 G-protein coupled receptor 1.8E-02 0.362 0.923 49
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 47
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 45
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 42