Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 151 0
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 146 14
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 103 3
AHR P35869 aryl hydrocarbon receptor Transcription factor 1.00 0.410 0.923 99 10
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 89 1
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 81 1
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 63 1
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923 62 3
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 48 2
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 41 27
IL6ST P40189 interleukin 6 signal transducer Signaling 1.00 0.475 0.808 36 4
CCL20 P78556 C-C motif chemokine ligand 20 Signaling 2.4E-04 0.474 0.846 36 2
CXCL9 Q07325 C-X-C motif chemokine ligand 9 Signaling 2.9E-03 0.462 0.808 35 1
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 35 0
IL13 P35225 interleukin 13 1.4E-02 0.386 0.846 34 6
EGR1 P18146 early growth response 1 Nucleic acid binding 0.35 0.433 0.923 32 0