Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4204
Gene Symbol: MECP2
MECP2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD A chromatin immunoprecipitation assay demonstrated that MeCP2 was associated with the MT-I promoter in the hepatoma implicating its involvement in repressing the methylated promoter. 11844796

2002

Entrez Id: 4176
Gene Symbol: MCM7
MCM7
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.220 SusceptibilityMutation RGD A genetic variant in the promoter region of miR-106b-25 cluster predict clinical outcome of HBV-related hepatocellular carcinoma in Chinese. 24416400

2014

Entrez Id: 406953
Gene Symbol: MIR18A
MIR18A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 ModifyingMutation RGD A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. 30191950

2019

Entrez Id: 407014
Gene Symbol: MIR25
MIR25
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 ModifyingMutation RGD A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. 30191950

2019

Entrez Id: 6722
Gene Symbol: SRF
SRF
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. 9570363

1997

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.660 Biomarker RGD Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis. 8446626

1993

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.270 Biomarker RGD Additionally, we show that plasma levels of cleaved IR reflect IR isoform A expression levels in liver tumors, which prompts us to propose that the measurement of circulating cleaved IR may assist hepatic cancer detection and management. 29610518

2018

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. 15509519

2004

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.510 Biomarker RGD Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. 12112319

2002

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Therapeutic RGD Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats. 22129741

2011

Entrez Id: 5111
Gene Symbol: PCNA
PCNA
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.230 Therapeutic RGD Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma. 23219601

2013

Entrez Id: 825
Gene Symbol: CAPN3
CAPN3
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD Calpain-3 gene expression is decreased during experimental cancer cachexia. 10806331

2000

Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.220 Biomarker RGD Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism. 17196522

2007

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.540 Biomarker RGD Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats. 17554210

2007

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.260 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018

Entrez Id: 2706
Gene Symbol: GJB2
GJB2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.210 Biomarker RGD CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats. 17295234

2007

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats. 17295234

2007

Entrez Id: 406900
Gene Symbol: MIR106B
MIR106B
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD Crosstalk between liver-related microRNAs and Wnt/β-catenin pathway in hepatocellular carcinoma patients. 28958640

2017

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.210 Biomarker RGD Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. 19309364

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.690 Biomarker RGD De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats. 12359353

2002

Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.240 Biomarker RGD Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. 25842354

2015

Entrez Id: 7409
Gene Symbol: VAV1
VAV1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture. 2064726

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.700 Biomarker RGD Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. 29429512

2018