Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.210 Biomarker RGD Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain. 19059387

2009

Entrez Id: 11255
Gene Symbol: HRH3
HRH3
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Histaminergic involvement in neuropathic pain produced by partial ligation of the sciatic nerve in rats. 17350523

2007

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. 21795534

2011

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Mammalian target of rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in the rat. 20452291

2010

Entrez Id: 5902
Gene Symbol: RANBP1
RANBP1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. 18667152

2008

Entrez Id: 7132
Gene Symbol: TNFRSF1A
TNFRSF1A
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. 11240015

2001

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Increased GSK-3β expression in DRG microglia in response to sciatic nerve crush. 27125978

2016

Entrez Id: 4099
Gene Symbol: MAG
MAG
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Therapeutic RGD Myelin-associated glycoprotein reduces axonal branching and enhances functional recovery after sciatic nerve transection in rats. 17705198

2007

Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. 29659443

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Therapeutic RGD Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. 22173123

2012

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. 22173123

2012

Entrez Id: 25898
Gene Symbol: RCHY1
RCHY1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Dynamic changes of PIRH2 and p27kip1 expression in injured rat sciatic nerve. 21959983

2012

Entrez Id: 57555
Gene Symbol: NLGN2
NLGN2
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy. 17492651

2007

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Therapeutic RGD Pharmacological activation of heme oxygenase (HO)-1/carbon monoxide pathway prevents the development of peripheral neuropathic pain in Wistar rats. 23224421

2013

Entrez Id: 4747
Gene Symbol: NEFL
NEFL
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy. 12638730

2003

Entrez Id: 8912
Gene Symbol: CACNA1H
CACNA1H
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury. 22972512

2013

Entrez Id: 9722
Gene Symbol: NOS1AP
NOS1AP
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. 17768032

2008

Entrez Id: 623
Gene Symbol: BDKRB1
BDKRB1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Role of kinin B1 and B2 receptors in a rat model of neuropathic pain. 18182225

2008

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury. 29970988

2018

Entrez Id: 6336
Gene Symbol: SCN10A
SCN10A
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats. 21965668

2011

Entrez Id: 823
Gene Symbol: CAPN1
CAPN1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Influence of electrical stimulation on calpain and ubiquitin-proteasome systems in the denervated and unloaded rat tibialis anterior muscles. 24745757

2014

Entrez Id: 386724
Gene Symbol: AMIGO3
AMIGO3
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury. 23613963

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1α-Sirt3 axis. 22996345

2012

Entrez Id: 5859
Gene Symbol: QARS1
QARS1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Expression profile of aminoacyl-tRNA synthetases in dorsal root ganglion neurons after peripheral nerve injury. 25467976

2015

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Therapeutic RGD Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. 21151668

2011