×
Entrez Id: 10020
Gene Symbol: GNE
GNE
Dementia
0.010
Biomarker
LHGDN
Clinical delineation and localization to chromosome 9p13.3-p12 of a unique dominant disorder in four families: hereditary inclusion body myopathy, Paget disease of bone, and frontotemporal dementia.
11749051 2001
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Dementia
0.200
GeneticVariation
LHGDN
Our results indicate that the PON2*S and apoE4 alleles have interactive effect on the development of the two most common forms of dementias AD and VD, and further support the hypothesis that cardiovascular factors contribute to the development of AD.
11803456 2002
×
Entrez Id: 5445
Gene Symbol: PON2
PON2
Dementia
0.010
GeneticVariation
LHGDN
Our results indicate that the PON2 *S and apoE4 alleles have interactive effect on the development of the two most common forms of dementias AD and VD, and further support the hypothesis that cardiovascular factors contribute to the development of AD.
11803456 2002
×
Entrez Id: 6507
Gene Symbol: SLC1A3
SLC1A3
Dementia
0.020
AlteredExpression
LHGDN
These findings suggest that EAAT1 changes are related to tau expression (and hence neurofibrillary tangle formation) in dementia cases showing Alzheimer-type pathology.
11826152 2002
×
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
Dementia
0.200
GeneticVariation
LHGDN
Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer's disease.
11836371 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Dementia
0.200
Biomarker
LHGDN
To investigate the role of this gene in the development of dementia associated with PD and age at onset of PD, we evaluated the frequency of APOE gene polymorphism in a sample of PD patients with (n=118) and without (n=167) a family history, as well as matched normal controls (n=96).
11863377 2002
×
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
Dementia
0.200
GeneticVariation
LHGDN
Molecular evidence of presenilin 1 mutation in familial early onset dementia .
11920851 2002
×
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
Dementia
0.200
GeneticVariation
LHGDN
Alternative transcripts of presenilin-1 associated with frontotemporal dementia.
11973477 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Dementia
0.200
GeneticVariation
LHGDN
Apolipoprotein E4 in the temporal variant of frontotemporal dementia.
12023438 2002
SERPINA1
Dementia
0.030
Biomarker
LHGDN
Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia.
12023831 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Dementia
0.200
GeneticVariation
LHGDN
Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis.
12107813 2002
×
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
Dementia
0.020
Biomarker
LHGDN
Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia.
12167619 2002
×
Entrez Id: 246744
Gene Symbol: STH
STH
Dementia
0.030
GeneticVariation
LHGDN
Is the saitohin gene involved in neurodegenerative diseases?
12447938 2002
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
Biomarker
LHGDN
Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval.
12476321 2002
×
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
Dementia
0.030
GeneticVariation
LHGDN
Debrisoquine hydroxylase gene polymorphism (CYP2D6*4) in dementia with Lewy bodies.
12486288 2003
×
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
Dementia
0.080
Biomarker
LHGDN
Impairment of secretory pattern of IGF-I from lymphomononuclear cells in aging and dementia of the Alzheimer's and vascular type.
12508915 2002
×
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
Dementia
0.010
AlteredExpression
LHGDN
Inhibition of long-term potentiation by interleukin-8 : implications for human immunodeficiency virus-1-associated dementia .
12548717 2003
×
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
Dementia
0.200
Biomarker
LHGDN
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies.
12576551 2003
×
Entrez Id: 5649
Gene Symbol: RELN
RELN
Dementia
0.020
AlteredExpression
LHGDN
Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease.
12645087 2003
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
Tau haplotype frequency in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
12710929 2003
×
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1
Dementia
0.040
Biomarker
LHGDN
Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.
12727313 2003
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family.
12796837 2003
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Dementia
0.200
Biomarker
LHGDN
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects.
12876259 2003
×
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
Dementia
0.020
Biomarker
LHGDN
In contrast, CSF and brain tissue samples from HAD patients showed reduced TIMP-1 levels compared to seronegative controls.
12951656 2003
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Dementia
0.100
AlteredExpression
LHGDN
HIV-1 and IL-1 beta regulate Fas ligand expression in human astrocytes through the NF-kappa B pathway.
12965265 2003