×
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
Dementia
0.200
Biomarker
LHGDN
Dementia developed in 3 family members in this kindred at a mean age of 27 years; the proband had myoclonus, seizures, and rigidity, similar to findings in previously described kindreds with PSEN1 mutations.16344340 2005
×
Entrez Id: 5444
Gene Symbol: PON1
PON1
Dementia
0.060
GeneticVariation
LHGDN
Paraoxonase 1 gene polymorphisms and dementia in humans.15016430 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
GeneticVariation
LHGDN
APP is an important locus predicting the age at onset of dementia in people with Down syndrome.15184603 2004
×
Entrez Id: 6507
Gene Symbol: SLC1A3
SLC1A3
Dementia
0.020
Biomarker
LHGDN
EAAT1 parameters were mutually correlated (p<0.01) and correlations were shown with dementia severity (p<0.05 MMSE-expression, p<0.005 MMSE-mRNA).15718040 2005
×
Entrez Id: 25978
Gene Symbol: CHMP2B
CHMP2B
Dementia
0.190
GeneticVariation
LHGDN
CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia.16941655 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
Biomarker
LHGDN
APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage.17442758 2007
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
GeneticVariation
LHGDN
PGRN mutations at 17q21 may occur in apparently sporadic frontotemporal lobar dementia with ubiquitinated inclusions cases and in cases presenting with either primary progressive aphasia or the behavioral variant of frontotemporal dementia.17522386 2007
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Dementia
0.200
Biomarker
LHGDN
Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia .17659264 2007
×
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
Dementia
0.200
Biomarker
LHGDN
SNCA dosage is responsible for parkinsonism, autonomic dysfunction, and dementia observed within each family.18571778 2008
×
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
Dementia
0.010
Biomarker
LHGDN
A 5-HT(1A ) antagonist adjuvant may improve treatment of depression in dementia .
18841018 2008
×
Entrez Id: 351
Gene Symbol: APP
APP
Dementia
0.700
GeneticVariation
LHGDN
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.
18300294 2008
×
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
Dementia
0.500
GeneticVariation
LHGDN
A novel insertional mutation in the prion protein gene: clinical and bio-molecular findings.
19010951 2008
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
A novel MAPT mutation (P301T) associated with familial frontotemporal dementia.
17662000 2007
×
Entrez Id: 6400
Gene Symbol: SEL1L
SEL1L
Dementia
0.010
GeneticVariation
LHGDN
A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease.
16412574 2006
×
Entrez Id: 2896
Gene Symbol: GRN
GRN
Dementia
0.500
GeneticVariation
LHGDN
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
17439980 2007
×
Entrez Id: 57338
Gene Symbol: JPH3
JPH3
Dementia
0.120
Biomarker
LHGDN
A South African mixed ancestry family with Huntington disease-like 2: clinical and genetic features.
17708569 2007
×
Entrez Id: 215
Gene Symbol: ABCD1
ABCD1
Dementia
0.120
GeneticVariation
LHGDN
Adult onset cerebral form of X-linked adrenoleukodystrophy with dementia of frontal lobe type with new L160P mutation in ABCD1 gene.
17662307 2007
×
Entrez Id: 2332
Gene Symbol: FMR1
FMR1
Dementia
0.160
GeneticVariation
LHGDN
Age-dependent cognitive changes in carriers of the fragile X syndrome.
18472033 2008
×
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
Dementia
0.200
AlteredExpression
LHGDN
Alpha-synuclein overexpression model.
17017543 2006
×
Entrez Id: 5655
Gene Symbol: KLK10
KLK10
Dementia
0.010
Biomarker
LHGDN
Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.
14972646 2004
×
Entrez Id: 5650
Gene Symbol: KLK7
KLK7
Dementia
0.010
Biomarker
LHGDN
Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.
14972646 2004
×
Entrez Id: 5649
Gene Symbol: RELN
RELN
Dementia
0.020
AlteredExpression
LHGDN
Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease.
12645087 2003
×
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
Dementia
0.200
GeneticVariation
LHGDN
Alternative transcripts of presenilin-1 associated with frontotemporal dementia.
11973477 2002
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Dementia
0.500
GeneticVariation
LHGDN
Although rare, a tau-related dementia with mutations in the microtubule-associated protein tau gene (MAPT) has been identified in patients showing clinical presentations similar to those of AD.
18587238 2008
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Dementia
0.200
Biomarker
LHGDN
Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.
18322386 2008