Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.500 Biomarker MGD

Entrez Id: 374
Gene Symbol: AREG
AREG
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Increased expression of schwannoma-derived growth factor (SDGF) mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat gliomas. 8621257

1996

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells. 10078962

1999

Entrez Id: 941
Gene Symbol: CD80
CD80
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells. 10078962

1999

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells. 10078962

1999

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Therapeutic RGD Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. 10830965

2000

Entrez Id: 8089
Gene Symbol: YEATS4
YEATS4
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. 11521196

2001

Entrez Id: 6480
Gene Symbol: ST6GAL1
ST6GAL1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Therapeutic RGD Thus, manipulating ST6Gal I gene expression may have therapeutic potential for the treatment of malignant gliomas. 11559557

2001

Entrez Id: 63827
Gene Symbol: BCAN
BCAN
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 ModifyingMutation RGD Brain enriched hyaluronan binding (BEHAB)/brevican increases aggressiveness of CNS-1 gliomas in Lewis rats. 11585735

2001

Entrez Id: 63827
Gene Symbol: BCAN
BCAN
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma. 12799382

2003

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Alteration of striatal dopaminergic function induced by glioma development: a microdialysis and immunohistological study in the rat striatum. 14698456

2004

Entrez Id: 1435
Gene Symbol: CSF1
CSF1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma. 15728459

2005

Entrez Id: 5110
Gene Symbol: PCMT1
PCMT1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Expression and activity of l-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors. 15857672

2005

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Therapeutic RGD The role of thrombin in gliomas. 15975137

2005

Entrez Id: 2833
Gene Symbol: CXCR3
CXCR3
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD Chemokine-directed migration of tumor-inhibitory neural progenitor cells towards an intracranially growing glioma. 16434036

2006

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.560 Biomarker RGD Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633

2006

Entrez Id: 3371
Gene Symbol: TNC
TNC
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.220 Biomarker RGD Human monoclonal antibodies to domain C of tenascin-C selectively target solid tumors in vivo. 16928692

2006

Entrez Id: 572
Gene Symbol: BAD
BAD
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model. 16944316

2006

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. 17287256

2007

Entrez Id: 8877
Gene Symbol: SPHK1
SPHK1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. 17316399

2007

Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Intracranial stereotaxic cannulation for development of orthotopic glioblastoma allograft in Sprague-Dawley rats and histoimmunopathological characterization of the brain tumor. 17701349

2007

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.220 Biomarker RGD In vivo detection of c-Met expression in a rat C6 glioma model. 18194445

2008

Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study. 18615861

2008

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.260 Therapeutic RGD Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. 19292920

2009

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.260 Biomarker RGD Reduction of Akt2 inhibits migration and invasion of glioma cells. 19330838

2009