Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker LHGDN Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo. 17710156

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 AlteredExpression LHGDN Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. 17149612

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance. 15943410

2005

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Approximately 50% of colorectal tumors contain K-ras gene mutations, which occur as an early step in carcinogenesis. 15514939

2005

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 PosttranslationalModification LHGDN BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. 15489648

2004

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. 19002263

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. 18834226

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Detection of a K-ras mutation in urine of patients with colorectal cancer. 17192038

2005

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Dual effect of Kras(D12) knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy. 16091732

2005

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers. 16918136

2006

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. 17704924

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice. 19056857

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations. 17707462

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer. 17393356

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma. 17465446

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. 19164213

2009

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma. 17663506

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN K-ras mutation detection in colorectal cancer using the Pyrosequencing technique. 17629419

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN K-ras mutations and RASSF1A promoter methylation in colorectal cancer. 12032847

2002

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. 16953233

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS mutation profile in colorectal carcinoma and novel mutation--internal tandem duplication in KRAS. 18669174

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. 19124802

2009

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. 18202412

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker LHGDN KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. 17998284

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. 16760301

2006