×
Entrez Id:
5506
Gene Symbol:
PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000
Biomarker
MGD
Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance.
12606498
2003
×
Entrez Id:
208
Gene Symbol:
AKT2
AKT2
Diabetes Mellitus, Non-Insulin-Dependent
0.960
Biomarker
MGD
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
11387480
2001
×
Entrez Id:
2645
Gene Symbol:
GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
MGD
Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.
8530440
1995
×
Entrez Id:
3667
Gene Symbol:
IRS1
IRS1
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
MGD
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
7969452
1994
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Diabetes Mellitus, Non-Insulin-Dependent
0.900
Biomarker
MGD
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.
9566924
1998
×
Entrez Id:
6517
Gene Symbol:
SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800
Biomarker
MGD
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.
9312184
1997
×
Entrez Id:
6517
Gene Symbol:
SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800
Biomarker
MGD
The male GLUT4 +/- mice represent a good model for studying the development of NIDDM without the complications associated with obesity.
9334720
1997
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Thus, p27(Kip1) contributes to beta-cell failure during the development of type 2 diabetes in Irs2 (-/-) and Lepr(-/-) mice and represents a potential new target for the treatment of this condition.
15685168
2005
×
Entrez Id:
6514
Gene Symbol:
SLC2A2
SLC2A2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2.
9354799
1997
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
It has been reported that insulin receptor substrate (IRS)-1 deficient (IRS-1-/-) mice showed insulin resistance without type 2 diabetes , whereas the IRS-2 deficient (IRS-2 -/-) mice showed insulin resistance with type 2 diabetes .
12810606
2003
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
IRS-2 pathways integrate female reproduction and energy homeostasis.
11014193
2000
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Although homozygous IRS-2 -deficient mice (IRS-2 -/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks.
11078455
2000
×
Entrez Id:
3630
Gene Symbol:
INS
INS
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
17911348
2007
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.
11259600
2001
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Insulin signaling after exercise in insulin receptor substrate-2-deficient mice.
11812758
2002
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
The insulin receptor substrate-2 (Irs2 ) branch of the insulin/IGF signaling system coordinates peripheral insulin action and pancreatic beta cell function, so mice lacking Irs2 display similarities to humans with type 2 diabetes .
14617753
2003
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
×
Entrez Id:
3159
Gene Symbol:
HMGA1
HMGA1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Loss of Hmga1 expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major targets of insulin action, largely impaired insulin signaling and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes .
15924147
2005
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
18288891
2008
×
Entrez Id:
8660
Gene Symbol:
IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
MGD
Our results indicate that dysfunction of IRS-2 may contribute to the pathophysiology of human type 2 diabetes .
9495343
1998
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
Diabetes Mellitus, Non-Insulin-Dependent
0.600
Biomarker
MGD
Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver.
15309293
2004
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
Diabetes Mellitus, Non-Insulin-Dependent
0.600
Biomarker
MGD
COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice.
15885672
2005
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
Diabetes Mellitus, Non-Insulin-Dependent
0.600
Biomarker
MGD
Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance.
17095713
2007
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
Diabetes Mellitus, Non-Insulin-Dependent
0.600
Biomarker
MGD
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.
24332968
2014
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
Diabetes Mellitus, Non-Insulin-Dependent
0.600
Biomarker
MGD
Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis.
22609345
2012