Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.300 Biomarker RGD Here, we have analyzed the localization of COX-1 and COX-2 in rat experimental autoimmune encephalomyelitis (EAE), C6 glioblastoma and 9L gliosarcoma by immunohistochemistry. 10229132

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.300 Biomarker RGD Here, we have analyzed the localization of COX-1 and COX-2 in rat experimental autoimmune encephalomyelitis (EAE), C6 glioblastoma and 9L gliosarcoma by immunohistochemistry. 10229132

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Experimental Autoimmune Encephalomyelitis
0.200 Biomarker RGD In EAE, we observed an increase in COX-1+ macrophages/microglial cells and COX-2+ endothelial cells that was closely linked to disease progression. 10229132

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0206726
Disease: gliosarcoma
gliosarcoma
0.200 Biomarker RGD Here, we have analyzed the localization of COX-1 and COX-2 in rat experimental autoimmune encephalomyelitis (EAE), C6 glioblastoma and 9L gliosarcoma by immunohistochemistry. 10229132

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1514422
Disease: Glioblastoma, IDH-Wildtype
Glioblastoma, IDH-Wildtype
0.200 Biomarker RGD Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. 10229132

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.600 Biomarker RGD In total, Cox-2 mRNA expression was down-regulated in eight out of ten Eker RCs and cell lines, while Cox-1 mRNA expression was up-regulated in nine out of ten Eker RCs and cell lines. 12708469

2003

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.500 Biomarker RGD Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats. 12535784

2003

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027814
Disease: Neuritis, Autoimmune, Experimental
Neuritis, Autoimmune, Experimental
0.200 Biomarker RGD Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis. 12916703

2003

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker RGD We also aimed to investigate whether celecoxib, a specific cyclooxygenase 2 (COX-2) inhibitor, would affect secondary hyperalgesia. 15464832

2004

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker RGD Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses. 15775781

2005

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.500 Biomarker RGD Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. 16247333

2005

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Other specified forms of pleural effusion, except tuberculous
0.200 Biomarker RGD Local and systemic expression of inducible nitric oxide synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy. 15740981

2005

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker RGD We have tested the hypothesis that in hypertension elevated ROS levels may modify the expression of NOS1 and COX-2 in the JGA, thereby interacting with juxtaglomerular signaling. 16467505

2006

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders
0.210 Biomarker RGD Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. 16781689

2006

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.600 Biomarker RGD COX-2 may play an important role in esophageal carcinogenesis through the activation of the inflammation-metaplasia-adenocarcinoma sequence. 17675820

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus
0.600 Biomarker RGD [Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide]. 17675820

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009319
Disease: Colitis
Colitis
0.600 Therapeutic RGD Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. 17543437

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer
0.600 Biomarker RGD These results confirmed the importance of COX-2/PGE2 in the healing mechanism of gastric ulcers and further suggested that the healing-promoting action of PGE2 is mediated by the activation of EP4 receptors and is associated with VEGF expression. 17673547

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021368
Disease: Inflammation
Inflammation
0.570 Biomarker RGD Anti-inflammatory and analgesic actions of etoricoxib (an NSAID) combined with misoprostol. 17701021

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.550 Biomarker RGD A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor. 17881518

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker RGD Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes. 17720896

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0270824
Disease: Visual seizure
Visual seizure
0.500 Biomarker RGD Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. 17827730

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.300 Biomarker RGD Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. 17429720

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.270 Biomarker RGD Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats. 17112505

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.270 Biomarker RGD Effect of intramuscular injection of hepatocyte growth factor plasmid DNA with electroporation on bleomycin-induced lung fibrosis in rats. 17825173

2007