Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies 		0.200 Biomarker RGD Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats. 21951301

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.200 Biomarker RGD Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. 21643627

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.200 Biomarker RGD Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats. 21362433

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021843
Disease: Intestinal Obstruction
Intestinal Obstruction 		0.200 Biomarker RGD In conclusion, mechanical stretch in obstruction induces marked expression of COX-2 in the colonic SMC, and stretch-induced COX-2 plays a critical role in the suppression of smooth muscle contractility in bowel obstruction. 21051526

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 Biomarker RGD Study on cow ghee versus soybean oil on 7,12-dimethylbenz(a)-anthracene induced mammary carcinogenesis & expression of cyclooxygenase-2 & peroxisome proliferators activated receptor-γ in rats. 21623034

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.200 Biomarker RGD Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity. 21893983

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.200 Biomarker RGD Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain. 21385433

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0024624
Disease: Malignant neoplasm of upper lobe, bronchus or lung
Malignant neoplasm of upper lobe, bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0029607
Disease: Other emphysema
Other emphysema 		0.200 Biomarker RGD Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema. 20472710

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0153491
Disease: Malignant neoplasm of middle lobe, bronchus or lung
Malignant neoplasm of middle lobe, bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0153492
Disease: Malignant neoplasm of lower lobe, bronchus or lung
Malignant neoplasm of lower lobe, bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0153493
Disease: Malignant neoplasm of other parts of bronchus or lung
Malignant neoplasm of other parts of bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0029799
Disease: Other specified forms of pleural effusion, except tuberculous
Other specified forms of pleural effusion, except tuberculous 		0.200 Biomarker RGD Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. 20141620

2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.200 Biomarker RGD [The effect of nitric oxide inhalation on the expression of COX-2 and toll-like receptor 4 in rat acute lung injury induced by lipopolysaccharide]. 19567182

2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002624
Disease: Retrograde amnesia
Retrograde amnesia 		0.200 Biomarker RGD Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT. 18523723

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002792
Disease: anaphylaxis
anaphylaxis 		0.200 Biomarker RGD The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition. 18480553

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 Biomarker RGD Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model. 18279516

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0043121
Disease: Wernicke Encephalopathy
Wernicke Encephalopathy 		0.200 Biomarker RGD Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. 18481165

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.200 Biomarker RGD Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. 18373278

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C2676033
Disease: Hepatoblastoma Caused By Somatic Mutation
Hepatoblastoma Caused By Somatic Mutation 		0.200 Biomarker RGD Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. 18373278

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies 		0.200 Biomarker RGD Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes. 17720896

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension 		0.200 Biomarker RGD Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. 17876871

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Biomarker RGD COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia. 17660401

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0375359
Disease: Chronic left-sided ulcerative colitis
Chronic left-sided ulcerative colitis 		0.200 Biomarker RGD Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. 17429720

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0029799
Disease: Other specified forms of pleural effusion, except tuberculous
Other specified forms of pleural effusion, except tuberculous 		0.200 Biomarker RGD Local and systemic expression of inducible nitric oxide synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy. 15740981

2005