Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker RGD Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses. 15775781

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.600 Biomarker RGD COX-2 may play an important role in esophageal carcinogenesis through the activation of the inflammation-metaplasia-adenocarcinoma sequence. 17675820

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.550 Biomarker RGD A 3-day treatment with the cox-2 inhibitor SC-58236 (SC) was started 1 day before electrically induced SE. 20643531

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.550 Biomarker RGD A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor. 17881518

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.600 Biomarker RGD A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model. 20056215

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.300 Biomarker RGD Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. 17429720

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0375359
Disease: Chronic left-sided ulcerative colitis
Chronic left-sided ulcerative colitis 		0.200 Biomarker RGD Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. 17429720

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021368
Disease: Inflammation
Inflammation 		0.570 Biomarker RGD Alvimopan and COX-2 inhibition reverse opioid and inflammatory components of postoperative ileus. 18266613

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021368
Disease: Inflammation
Inflammation 		0.570 Biomarker RGD Anti-inflammatory and analgesic actions of etoricoxib (an NSAID) combined with misoprostol. 17701021

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0029607
Disease: Other emphysema
Other emphysema 		0.200 Biomarker RGD Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema. 20472710

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0029799
Disease: Other specified forms of pleural effusion, except tuberculous
Other specified forms of pleural effusion, except tuberculous 		0.200 Biomarker RGD Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. 20141620

2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0015967
Disease: Fever
Fever 		0.590 Biomarker RGD As significant findings, compounds 1-3 demonstrated potent COX-2 inhibitory activities with high selectivities for COX-2 over COX-1 in human cells or whole-blood in vitro, and demonstrated orally potent anti-pyretic activity against lipopolysaccharide-induced systemic-inflammatory fever model in F344 rats. 21741371

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002624
Disease: Retrograde amnesia
Retrograde amnesia 		0.200 Biomarker RGD Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT. 18523723

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.230 Biomarker RGD Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. 21643627

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.200 Biomarker RGD Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. 21643627

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0149721
Disease: Left Ventricular Hypertrophy
Left Ventricular Hypertrophy 		0.210 Biomarker RGD Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat. 18542928

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.200 Biomarker RGD Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity. 21893983

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.600 Biomarker RGD Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma. 22165968

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017152
Disease: Gastritis
Gastritis 		0.300 Biomarker RGD Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor. 18646190

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0024624
Disease: Malignant neoplasm of upper lobe, bronchus or lung
Malignant neoplasm of upper lobe, bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0153491
Disease: Malignant neoplasm of middle lobe, bronchus or lung
Malignant neoplasm of middle lobe, bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0153492
Disease: Malignant neoplasm of lower lobe, bronchus or lung
Malignant neoplasm of lower lobe, bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0153493
Disease: Malignant neoplasm of other parts of bronchus or lung
Malignant neoplasm of other parts of bronchus or lung 		0.200 Biomarker RGD Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. 21303331

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 Biomarker RGD Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model. 18279516

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Biomarker RGD COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia. 17660401

2007