Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Therapeutic RGD Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. 29126976

2018

Entrez Id: 23236
Gene Symbol: PLCB1
PLCB1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker MGD

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 8754
Gene Symbol: ADAM9
ADAM9
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Biomarker RGD Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain. 24792732

2014

Entrez Id: 599
Gene Symbol: BCL2L2
BCL2L2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Therapeutic RGD Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. 20460763

2010

Entrez Id: 538
Gene Symbol: ATP7A
ATP7A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Biomarker RGD Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. 20027333

2009

Entrez Id: 723961
Gene Symbol: INS-IGF2
INS-IGF2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Biomarker RGD Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. 17448147

2007

Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Biomarker RGD Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat. 16914836

2006

Entrez Id: 3551
Gene Symbol: IKBKB
IKBKB
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.220 Therapeutic RGD Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42. 24380241

2013

Entrez Id: 5176
Gene Symbol: SERPINF1
SERPINF1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.220 Biomarker RGD Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition test and Morris water maze. 17073149

2006

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.230 Therapeutic RGD Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ 29642617

2018

Entrez Id: 3315
Gene Symbol: HSPB1
HSPB1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.230 Biomarker RGD Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. 25772164

2015

Entrez Id: 10519
Gene Symbol: CIB1
CIB1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.230 Biomarker RGD In AD brain a substantial loss of Calmyrin-immunopositive neurones was observed in all regions, especially in cortical areas. 15885068

2005

Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.240 Therapeutic RGD Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. 19374888

2009

Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.240 Biomarker RGD Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease. 15802185

2005

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.240 Biomarker RGD The present study suggests that DAPTA and other CCR5 antagonists may attenuate critical aspects of the neuroinflammation associated with Alzheimer's disease. 15979806

2005

Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.240 Biomarker MGD

Entrez Id: 3297
Gene Symbol: HSF1
HSF1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.250 Biomarker RGD Even more interesting, injection of lentivirus vector-HSF1 into the cerebella of AD rats significantly increased HSF1 and HSP expression levels and induced an increase in the number of Purkinje cell bodies. 23665061

2013

Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.260 Biomarker RGD Swimming attenuates d-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics. 28302704

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.260 Biomarker RGD Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain. 24792732

2014

Entrez Id: 1759
Gene Symbol: DNM1
DNM1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.260 Biomarker RGD Significant decreases in protein levels of dynamin I, AP180, and synaptophysin were observed in both AD patients and mice with AβPPSWE as compared to controls. 20847448

2010

Entrez Id: 334
Gene Symbol: APLP2
APLP2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.260 Biomarker RGD Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues. 8086458

1994

Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.280 Biomarker RGD Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic Alzheimer's disease in rats. 21701788

2012

Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.290 Therapeutic RGD Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer's disease rats. 24877042

2014

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.290 Biomarker MGD