Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Biomarker MGD

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker MGD

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.680 Biomarker MGD

Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker MGD

Entrez Id: 5300
Gene Symbol: PIN1
PIN1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker MGD

Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker MGD

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.290 Biomarker MGD

Entrez Id: 90865
Gene Symbol: IL33
IL33
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.240 Biomarker MGD

Entrez Id: 23236
Gene Symbol: PLCB1
PLCB1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker MGD

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD "Xiusanzhen" can regulate the expression of hippocampal Bcl-2 and Bax proteins in AD rats, which may contribute to its clinical effect in relieving AD, and the therapeutic effect depends on the integrity of the olfactory nerve pathway. 21585051

2011

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Therapeutic RGD "Xiusanzhen" can regulate the expression of hippocampal Bcl-2 and Bax proteins in AD rats, which may contribute to its clinical effect in relieving AD, and the therapeutic effect depends on the integrity of the olfactory nerve pathway. 21585051

2011

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. 28342971

2017

Entrez Id: 3551
Gene Symbol: IKBKB
IKBKB
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.220 Therapeutic RGD Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42. 24380241

2013

Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker RGD Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. 23296102

2013

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Therapeutic RGD Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. 12610652

2003

Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Therapeutic RGD After 28-day administration of NEK and piracetam, the abilities of learning and memory of AD rats in piracetam and low-dose, medium-dose and high-dose NEK groups were significantly improved as compared with the untreated group (P<0.01 or P<0.05); the expression of Abeta(1-42) in hippocampal tissues was decreased (P<0.01 or P<0.05) and the expression of NEP was increased (P<0.01 or P<0.05), especially in the high-dose NEK group. 20141738

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker RGD Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway. 22963993

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity. 25296496

2014

Entrez Id: 4133
Gene Symbol: MAP2
MAP2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker RGD An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide. 22083255

2012

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD Antioxidative and Neuroprotective Effects of Curcumin in an Alzheimer's Disease Rat Model Co-Treated with Intracerebroventricular Streptozotocin and Subcutaneous D-Galactose. 27060945

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 599
Gene Symbol: BCL2L2
BCL2L2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Therapeutic RGD Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. 20460763

2010

Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker RGD Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease. 21368378

2011