×
Entrez Id: 55340
Gene Symbol: GIMAP5
GIMAP5
Diabetes Mellitus, Insulin-Dependent
0.250
Biomarker
RGD
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
12097339 2002
×
Entrez Id: 55340
Gene Symbol: GIMAP5
GIMAP5
Diabetes Mellitus, Insulin-Dependent
0.250
Biomarker
RGD
The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.
12031988 2002
×
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
Diabetes Mellitus, Insulin-Dependent
0.220
Biomarker
RGD
Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes.
23111281 2013
×
Entrez Id: 3240
Gene Symbol: HP
HP
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
RGD
The identification and validation of haptoglobin as a putative serum biomarker for autoimmune T1D in rats now affords us the opportunity to test the validity of this protein as a biomarker for human T1D , particularly in those situations where viral infection is believed to precede the onset of disease.
20975081 2010
×
Entrez Id: 3240
Gene Symbol: HP
HP
Diabetes Mellitus, Insulin-Dependent
0.600
Therapeutic
RGD
Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat.
20853098 2010
×
Entrez Id: 3382
Gene Symbol: ICA1
ICA1
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
RGD
ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide.
11751995 2002
×
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
RGD
The role of endogenous interferon-gamma (IFN gamma) in the development of insulin-dependent diabetes mellitus (IDDM ) in diabetes-prone BB rats was evaluated.
8977415 1997
×
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
MGD
IFN-gamma affects homing of diabetogenic T cells.
11714835 2001
×
Entrez Id: 3460
Gene Symbol: IFNGR2
IFNGR2
Diabetes Mellitus, Insulin-Dependent
0.200
Biomarker
MGD
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.
11118001 2000
×
Entrez Id: 3460
Gene Symbol: IFNGR2
IFNGR2
Diabetes Mellitus, Insulin-Dependent
0.200
Biomarker
MGD
IFN-gamma affects homing of diabetogenic T cells.
11714835 2001
×
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
RGD
Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.
11307180 2001
×
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
×
Entrez Id: 3554
Gene Symbol: IL1R1
IL1R1
Diabetes Mellitus, Insulin-Dependent
0.240
Biomarker
MGD
IL-1 receptor deficiency slows progression to diabetes in the NOD mouse.
14693705 2004
×
Entrez Id: 3565
Gene Symbol: IL4
IL4
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
Interleukin-4 deficiency does not exacerbate disease in NOD mice.
9703318 1998
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
CTD_mouse
A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
17151334 2007
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
CTD_mouse
Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice.
29420703 2018
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
MGD
Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.
22297672 2012
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
MGD
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.
12925730 2003
×
Entrez Id: 11213
Gene Symbol: IRAK3
IRAK3
Diabetes Mellitus, Insulin-Dependent
0.200
Biomarker
MGD
IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice.
24696448 2014
×
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
Diabetes Mellitus, Insulin-Dependent
0.240
Biomarker
RGD
In summary, combined proteome-transcriptome-genome and functional analyses identify gal-3 as a candidate gene/protein in T1D susceptibility that may prove valuable in future intervention/prevention strategies.
16600178 2006
×
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.
9308961 1997
×
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
Diabetes Mellitus, Insulin-Dependent
0.250
Biomarker
MGD
×
Entrez Id: 3651
Gene Symbol: PDX1
PDX1
Diabetes Mellitus, Insulin-Dependent
0.260
Biomarker
MGD
×
Entrez Id: 5551
Gene Symbol: PRF1
PRF1
Diabetes Mellitus, Insulin-Dependent
0.210
Biomarker
MGD
Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules.
10946317 2000
×
Entrez Id: 5644
Gene Symbol: PRSS1
PRSS1
Diabetes Mellitus, Insulin-Dependent
0.310
Biomarker
RGD
Rat trypsin: purification, radioimmunoassay and age-related serum levels in normal and spontaneously diabetic BB Wistar rats.
3833185 1985