Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10014
Gene Symbol: HDAC5
HDAC5
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. 21416250

2011

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride. 11768240

2001

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats. 18612803

2008

Entrez Id: 5724
Gene Symbol: PTAFR
PTAFR
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Role of platelet activating factor in endotoxemic acute renal failure in the male rat. 2538527

1989

Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. 16557226

2006

Entrez Id: 552
Gene Symbol: AVPR1A
AVPR1A
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy. 17347933

2006

Entrez Id: 2837
Gene Symbol: UTS2R
UTS2R
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System. 15146030

2004

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Attenuation of glycerol-induced acute kidney injury by previous partial hepatectomy: role of hepatocyte growth factor/c-met axis in tubular protection. 17940345

2007

Entrez Id: 4151
Gene Symbol: MB
MB
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. 9822635

1998

Entrez Id: 6580
Gene Symbol: SLC22A1
SLC22A1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury. 22414646

2012

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. 22551254

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity. 21893983

2011

Entrez Id: 1594
Gene Symbol: CYP27B1
CYP27B1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Changes in 25-hydroxyvitamin D3 alpha- and 24-hydroxylase activities of kidney cells isolated from rats with either unilateral kidney damage or acute renal insufficiency. 6223803

1983

Entrez Id: 8841
Gene Symbol: HDAC3
HDAC3
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. 21416250

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats. 22750969

2012

Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. 16762988

2006

Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. 22571266

2012

Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Effects of glycerol-induced acute renal failure on tissue glutathione and glutathione-dependent enzymes in the rat. 1870354

1991

Entrez Id: 54361
Gene Symbol: WNT4
WNT4
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. 12707392

2003

Entrez Id: 3280
Gene Symbol: HES1
HES1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Determination of relative Notch1 and gamma-secretase-related gene expression in puromycin-treated microdissected rat kidneys. 24397211

2013

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Renal beta(2)-adrenoceptor modulates the lipopolysaccharide transport system in sepsis-induced acute renal failure. 19020966

2009

Entrez Id: 4714
Gene Symbol: NDUFB8
NDUFB8
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Persistent disruption of mitochondrial homeostasis after acute kidney injury. 22160772

2012

Entrez Id: 2628
Gene Symbol: GATM
GATM
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Interrelation of urinary and plasma levels of guanidinoacetic acid with alteration in renal activity of glycine amidinotransferase in acute renal failure rats. 2752493

1989

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD beta(2)-Adrenoceptor activation attenuates endotoxin-induced acute renal failure. 14747378

2004

Entrez Id: 407015
Gene Symbol: MIR26A1
MIR26A1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD A scrutiny of circulating microRNA biomarkers for drug-induced tubular and glomerular injury in rats. 30682439

2019