Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5901
Gene Symbol: RAN
RAN
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. 18667152

2008

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Therapeutic RGD Substrate-mediated nanoparticle/gene delivery to MSC spheroids and their applications in peripheral nerve regeneration. 24388817

2014

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Application of angiotensin II to healthy rat sciatic nerve can produce neuropathy without associated vasculopathy. 20886512

2010

Entrez Id: 4744
Gene Symbol: NEFH
NEFH
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD mRNA levels of all three neurofilament proteins decline following nerve transection. 3135913

1988

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Therapeutic RGD Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats. 25172308

2014

Entrez Id: 4987
Gene Symbol: OPRL1
OPRL1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Expression of ORL1 mRNA in some brain nuclei in neuropathic pain rats. 15862535

2005

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration. 19152028

2009

Entrez Id: 3283
Gene Symbol: HSD3B1
HSD3B1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury. 12648755

2003

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury. 17108688

2007

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Prolonged constriction of sciatic nerve affecting oxidative stressors & antioxidant enzymes in rat. 19675389

2009

Entrez Id: 8880
Gene Symbol: FUBP1
FUBP1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD FBP1 and p27kip1 expression after sciatic nerve injury: implications for Schwann cells proliferation and differentiation. 23939805

2014

Entrez Id: 3764
Gene Symbol: KCNJ8
KCNJ8
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. 21907492

2011

Entrez Id: 5125
Gene Symbol: PCSK5
PCSK5
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing. 9729404

1998

Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. 21907492

2011

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Therapeutic RGD Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. 22173123

2012

Entrez Id: 4922
Gene Symbol: NTS
NTS
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: a hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception. 8518953

1993

Entrez Id: 494330
Gene Symbol: MIR381
MIR381
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4. 30142543

2018

Entrez Id: 64802
Gene Symbol: NMNAT1
NMNAT1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. 16914673

2006

Entrez Id: 246213
Gene Symbol: SLC17A8
SLC17A8
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. 23835161

2013

Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. 2493483

1989

Entrez Id: 22938
Gene Symbol: SNW1
SNW1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Spatiotemporal expression of SKIP after rat sciatic nerve crush. 23389663

2013

Entrez Id: 5764
Gene Symbol: PTN
PTN
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain. 18365878

2008

Entrez Id: 407053
Gene Symbol: MIR96
MIR96
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury. 24234845

2014

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model. 22309829

2012

Entrez Id: 27297
Gene Symbol: CRCP
CRCP
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker RGD Localization and modulation of calcitonin gene-related peptide-receptor component protein-immunoreactive cells in the rat central and peripheral nervous systems. 12895509

2003