Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker RGD Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. 21268133

2011
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker RGD Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. 19694754

2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.560 Biomarker RGD These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1. 17404573

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 Biomarker RGD Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. 21268133

2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 ModifyingMutation RGD Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. 20428773

2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.530 Therapeutic RGD MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. 22641368

2012
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.520 Therapeutic RGD Further, 5-azacytidine potentiated cisplatin induced antitumor activity by involving decreased expression of pAKT, DNMT1 and an increased expression of p38 in colon tumors. 19723570

2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.340 Biomarker RGD In colon tumors relative to the mucosa, the protein and mRNA levels of c-myc were increased, while the levels of p16 and p27 were decreased. 12189186

2002
Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.210 ModifyingMutation RGD Effect of oral Lactococcus lactis containing endostatin on 1, 2-dimethylhydrazine-induced colon tumor in rats. 16437622

2005
Entrez Id: 3718
Gene Symbol: JAK3
JAK3
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.200 Therapeutic RGD Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy. 23514809

2013
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.200 ModifyingMutation RGD Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells. 15054094

2004
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.200 Biomarker RGD Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis. 14614307

2000
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.200 Biomarker RGD Xanthine oxidase activity in intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. 3163916

1988