Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.440 Biomarker HPO

Entrez Id: 1311
Gene Symbol: COMP
COMP
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.440 Biomarker HPO

Entrez Id: 8200
Gene Symbol: GDF5
GDF5
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.420 Biomarker GENOMICS_ENGLAND

Entrez Id: 8200
Gene Symbol: GDF5
GDF5
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.420 Biomarker HPO

Entrez Id: 8200
Gene Symbol: GDF5
GDF5
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.420 Biomarker GENOMICS_ENGLAND

Entrez Id: 1758
Gene Symbol: DMP1
DMP1
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.300 Biomarker GENOMICS_ENGLAND

Entrez Id: 1758
Gene Symbol: DMP1
DMP1
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.300 Biomarker GENOMICS_ENGLAND

Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.140 Biomarker HPO

Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.130 Biomarker HPO

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.110 Biomarker HPO

Entrez Id: 6399
Gene Symbol: TRAPPC2
TRAPPC2
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.100 Biomarker HPO

Entrez Id: 59341
Gene Symbol: TRPV4
TRPV4
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.100 Biomarker HPO

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.100 Biomarker HPO

Entrez Id: 1186
Gene Symbol: CLCN7
CLCN7
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.100 Biomarker HPO

Entrez Id: 1297
Gene Symbol: COL9A1
COL9A1
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.020 GeneticVariation BEFREE COL9A1 may therefore be a susceptibility locus for female hip OA. 10788539

2000
Entrez Id: 1302
Gene Symbol: COL11A2
COL11A2
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.010 Biomarker BEFREE In addition, there was weak evidence of linkage to HLA/COL11A2 (6p21.3) in female hip OA with a corrected P-value of 0.016. 10788539

2000
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.130 GeneticVariation BEFREE Haplotype analysis showed significant association between a specific haplotype of COL2A1 and hip OA (p = 0.024; OR = 1.30). 12096843

2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.050 Biomarker BEFREE The IL-1 ligand cluster encodes for susceptibility to knee OA but not to hip OA, highlighting the genetic heterogeneity of this common, complex disease. 12115182

2002
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.030 Biomarker BEFREE The IL-1 ligand cluster encodes for susceptibility to knee OA but not to hip OA, highlighting the genetic heterogeneity of this common, complex disease. 12115182

2002
Entrez Id: 4146
Gene Symbol: MATN1
MATN1
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.010 GeneticVariation BEFREE We compared genotype frequencies of the MATN-1 gene (1p35) in patients with OA and controls to determine if there is any association between the MATN-1 genotype and OA. 12175111

2003
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.140 GeneticVariation BEFREE Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. 15210948

2004
Entrez Id: 2487
Gene Symbol: FRZB
FRZB
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.140 GeneticVariation LHGDN Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. 15210948

2004
Entrez Id: 7130
Gene Symbol: TNFAIP6
TNFAIP6
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.010 GeneticVariation BEFREE However, genotyping showed lack of association for a nonsynonymous single-nucleotide polymorphism in tumor necrosis factor alpha-induced protein 6, whereas a single-nucleotide polymorphism in FRZB resulting in an Arg324Gly substitution at the carboxyl terminus was associated with hip OA in the female probands (P = 0.04). 15210948

2004
Entrez Id: 3566
Gene Symbol: IL4R
IL4R
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.010 GeneticVariation BEFREE Our data suggest that functional variants within the IL4R gene predispose to hip OA in Caucasian females. 14745651

2004
Entrez Id: 3566
Gene Symbol: IL4R
IL4R
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.010 GeneticVariation LHGDN Our data suggest that functional variants within the IL4R gene predispose to hip OA in Caucasian females. 14745651

2004