×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Molecular cloning and characterization of splice variants of human RAD50 gene.
10415333 1999
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
10892749 2000
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility.
14684699 2003
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Evaluation of RAD50 in familial breast cancer predisposition.
16385572 2006
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.
16474176 2006
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Evaluation of RAD50 in familial breast cancer predisposition.
16385572 2006
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette.
17386254 2007
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers.
18281469 2008
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Breast cancer susceptibility: current knowledge and implications for genetic counselling.
19092773 2009
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
19409520 2009
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population.
19190165 2009
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
19409520 2009
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID.
20805886 2010
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.
21035407 2010
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
RAD50 gene mutations are not likely a risk factor for breast cancer in Poland.
20571869 2010
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Some common mutations of RAD50 and NBS1 in western populations do not contribute significantly to Chinese non-BRCA1/2 hereditary breast cancer.
19904603 2010
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
21441914 2011
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
RAD50 and NBS1 are not likely to be susceptibility genes in Chinese non-BRCA1/2 hereditary breast cancer.
21811815 2012
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia.
24093751 2013
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes.
24549055 2014
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.
24763289 2014
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes.
24549055 2014
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.
24240112 2014
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
GeneticVariation
CLINVAR
Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.
24894818 2014
×
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Neoplastic Syndromes, Hereditary
0.100
CausalMutation
CLINVAR
Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.
24894818 2014