×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
OSTEOGENESIS IMPERFECTA, TYPE XVII
0.700
Biomarker
CTD_human
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Osteogenesis Imperfecta
0.520
Biomarker
CTD_human
Morphological and biochemical studies of a mouse mutant (fro/fro) with bone fragility.
1793673
1991
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Lobstein Disease
0.300
Biomarker
CTD_human
Morphological and biochemical studies of a mouse mutant (fro/fro) with bone fragility.
1793673
1991
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Kidney Diseases
0.330
Biomarker
CTD_human
Amelioration of diabetic nephropathy in SPARC-null mice.
12660331
2003
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Myocardial Ischemia
0.310
Biomarker
CTD_human
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
16214533
2005
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Malignant tumor of colon
0.340
Biomarker
CTD_human
Immunohistochemical analysis showed that SPARC expression was downregulated or absent in 17 of 20 colon cancers .
17397030
2007
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Colonic Neoplasms
0.310
Biomarker
CTD_human
Frequent inactivation of SPARC by promoter hypermethylation in colon cancers.
17397030
2007
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Liver Cirrhosis, Experimental
0.500
Biomarker
CTD_human
Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats.
18615449
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Liver Cirrhosis, Experimental
0.500
Therapeutic
CTD_human
Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats.
18615449
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Colorectal Carcinoma
0.400
Biomarker
CTD_human
We also demonstrate that SPARC repression in CRC cell lines could be reversed following exposure to 5-Aza, which resulted in increased SPARC expression, leading to a significant reduction in cell viability (by an additional 39% in RKO cells) and greater apoptosis (an additional 18% in RKO cells), when combined with 5-FU in vitro (in comparison to 5-FU alone).
18458674
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Leukemia, Myelocytic, Acute
0.330
Biomarker
CTD_human
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
18206229
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Multiple Myeloma
0.320
Biomarker
CTD_human
Moreover, SPARC methylation was associated with loss of SPARC protein expression by immunostaining in a subset of MM patients.
18172295
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Colorectal Neoplasms
0.300
Biomarker
CTD_human
SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.
18458674
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Acute Myeloid Leukemia, M1
0.300
Biomarker
CTD_human
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
18206229
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Weight Gain
0.300
Biomarker
CTD_human
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
19030233
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Acute Myeloid Leukemia (AML-M2)
0.300
Biomarker
CTD_human
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
18206229
2008
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
ovarian neoplasm
0.380
Biomarker
CTD_human
Investigation of primary tumors revealed that the Sparc promoter is methylated in 68% of primary ovarian tumors and that the levels of SPARC protein decrease as the disease progresses from low to high grade.
19177197
2009
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Malignant neoplasm of ovary
0.380
Biomarker
CTD_human
Addition of exogenous SPARC , as well as ectopic expression by an adenoviral vector, resulted in decreased proliferation of ovarian cancer cell lines.
19177197
2009
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Uremia
0.300
Biomarker
CTD_human
A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia.
19092814
2009
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Neoplasms, Experimental
0.300
Therapeutic
CTD_human
Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53.
20164124
2010
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Intervertebral Disc Degeneration
0.330
Biomarker
CTD_human
Inactivation of the SPARC gene in mice results in premature intervertebral disc degeneration .
20714283
2011
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Hyperalgesia
0.300
Biomarker
CTD_human
Behavioral signs of chronic back pain in the SPARC-null mouse.
20714283
2011
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Low Back Pain
0.300
Biomarker
CTD_human
Behavioral signs of chronic back pain in the SPARC-null mouse.
20714283
2011
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Low Back Pain, Mechanical
0.300
Biomarker
CTD_human
Behavioral signs of chronic back pain in the SPARC-null mouse.
20714283
2011
×
Entrez Id:
6678
Gene Symbol:
SPARC
SPARC
Low Back Pain, Posterior Compartment
0.300
Biomarker
CTD_human
Behavioral signs of chronic back pain in the SPARC-null mouse.
20714283
2011