Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0268363
Disease: Osteogenesis imperfecta type IV (disorder)
Osteogenesis imperfecta type IV (disorder) 		0.300 GermlineCausalMutation ORPHANET Recessive osteogenesis imperfecta caused by missense mutations in SPARC. 26027498

2015
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.300 Biomarker CTD_human Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. 23408952

2013
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.300 Biomarker CTD_human Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. 23408952

2013
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0027540
Disease: Necrosis
Necrosis 		0.300 Biomarker CTD_human Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. 23408952

2013
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma 		0.300 Biomarker CTD_human Preclinical investigation of nanoparticle albumin-bound paclitaxel as a potential treatment for adrenocortical cancer. 22156929

2012
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0024031
Disease: Low Back Pain
Low Back Pain 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0423682
Disease: Low Back Pain, Mechanical
Low Back Pain, Mechanical 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0423689
Disease: Low Back Pain, Posterior Compartment
Low Back Pain, Posterior Compartment 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0577660
Disease: Low Back Pain, Postural
Low Back Pain, Postural 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0751648
Disease: Recurrent Low Back Pain
Recurrent Low Back Pain 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C2717759
Disease: Degenerative Intervertebral Discs
Degenerative Intervertebral Discs 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.300 Biomarker CTD_human Behavioral signs of chronic back pain in the SPARC-null mouse. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0027659
Disease: Neoplasms, Experimental
Neoplasms, Experimental 		0.300 Therapeutic CTD_human Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53. 20164124

2010
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0041948
Disease: Uremia
Uremia 		0.300 Biomarker CTD_human A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia. 19092814

2009
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.300 Biomarker CTD_human SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response. 18458674

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0026998
Disease: Acute Myeloid Leukemia, M1
Acute Myeloid Leukemia, M1 		0.300 Biomarker CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.300 Biomarker CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023931
Disease: Lobstein Disease
Lobstein Disease 		0.300 Biomarker CTD_human Morphological and biochemical studies of a mouse mutant (fro/fro) with bone fragility. 1793673

1991