Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C4225301
Disease: OSTEOGENESIS IMPERFECTA, TYPE XVII
OSTEOGENESIS IMPERFECTA, TYPE XVII 		0.700 GeneticVariation UNIPROT Recessive osteogenesis imperfecta caused by missense mutations in SPARC. 26027498

2015
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C4225301
Disease: OSTEOGENESIS IMPERFECTA, TYPE XVII
OSTEOGENESIS IMPERFECTA, TYPE XVII 		0.700 Biomarker GENOMICS_ENGLAND Recessive osteogenesis imperfecta caused by missense mutations in SPARC. 26027498

2015
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C4225301
Disease: OSTEOGENESIS IMPERFECTA, TYPE XVII
OSTEOGENESIS IMPERFECTA, TYPE XVII 		0.700 Biomarker GENOMICS_ENGLAND Recessive osteogenesis imperfecta caused by missense mutations in SPARC. 26027498

2015
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C4225301
Disease: OSTEOGENESIS IMPERFECTA, TYPE XVII
OSTEOGENESIS IMPERFECTA, TYPE XVII 		0.700 Biomarker CTD_human

Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0029434
Disease: Osteogenesis Imperfecta
Osteogenesis Imperfecta 		0.520 Biomarker GENOMICS_ENGLAND Recessive osteogenesis imperfecta caused by missense mutations in SPARC. 26027498

2015
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0029434
Disease: Osteogenesis Imperfecta
Osteogenesis Imperfecta 		0.520 Biomarker CTD_human Morphological and biochemical studies of a mouse mutant (fro/fro) with bone fragility. 1793673

1991
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker CTD_human Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats. 18615449

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats. 18615449

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.400 Biomarker CTD_human We also demonstrate that SPARC repression in CRC cell lines could be reversed following exposure to 5-Aza, which resulted in increased SPARC expression, leading to a significant reduction in cell viability (by an additional 39% in RKO cells) and greater apoptosis (an additional 18% in RKO cells), when combined with 5-FU in vitro (in comparison to 5-FU alone). 18458674

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.380 Biomarker CTD_human Investigation of primary tumors revealed that the Sparc promoter is methylated in 68% of primary ovarian tumors and that the levels of SPARC protein decrease as the disease progresses from low to high grade. 19177197

2009
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.380 Biomarker CTD_human Addition of exogenous SPARC, as well as ectopic expression by an adenoviral vector, resulted in decreased proliferation of ovarian cancer cell lines. 19177197

2009
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.340 Biomarker CTD_human Immunohistochemical analysis showed that SPARC expression was downregulated or absent in 17 of 20 colon cancers. 17397030

2007
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.330 Biomarker CTD_human Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. 23408952

2013
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration 		0.330 Biomarker CTD_human Inactivation of the SPARC gene in mice results in premature intervertebral disc degeneration. 20714283

2011
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.330 Biomarker CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.330 Biomarker CTD_human Amelioration of diabetic nephropathy in SPARC-null mice. 12660331

2003
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia 		0.320 Biomarker CTD_human Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental myelodysplastic syndrome. 27725143

2016
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.320 Biomarker CTD_human Moreover, SPARC methylation was associated with loss of SPARC protein expression by immunostaining in a subset of MM patients. 18172295

2008
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.310 Biomarker CTD_human Frequent inactivation of SPARC by promoter hypermethylation in colon cancers. 17397030

2007
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.310 Biomarker CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533

2005
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0268363
Disease: Osteogenesis imperfecta type IV (disorder)
Osteogenesis imperfecta type IV (disorder) 		0.300 GermlineCausalMutation ORPHANET Recessive osteogenesis imperfecta caused by missense mutations in SPARC. 26027498

2015
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.300 Biomarker CTD_human Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. 23408952

2013
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.300 Biomarker CTD_human Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. 23408952

2013