|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Also the role of HLA-DRB1 genotype has not been evaluated, though it's associated with fibrosis in autoimmune hepatitis.
|
27333038 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The present findings suggest that the gene or genes conferring susceptibility to AIH lie in the region centromeric to the HLA A locus between HLA C and DRB1.
|
9328330 |
1997 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our data indicate that type 1 AIH predisposition in a Venezuelan mestizo population of different ethnic backgrounds is associated with DRB1*1301 and DRB1*0301 alleles.
|
17927716 |
2007 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the DR4-specific sequence (Val 11 and His 13 at amino acid positions 11 and 13, respectively), but not particular Dw-associated DR4 sequence, in the first domain of the DRB1 chain contributes to susceptibility to autoimmune hepatitis among Japanese.
|
1350267 |
1992 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Studies of type 1 AIH have focused on the major histocompatibility complex (MHC), mapping susceptibility to the DRB1 region.
|
12447707 |
2002 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the HLA-DRB1*0403 allele differed among Japanese patients with AIH according to the presence or absence of anti-gAChR antibodies.
|
26807576 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles of 76 children with pAILD (autoimmune hepatitis [AIH], autoimmune sclerosing cholangitis [AISC], primary sclerosing cholangitis [PSC]) and of 50 healthy blood donors as control group were analyzed retrospectively.
|
26567543 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
In subtypes of DR4, there was a trend of increase in the gene frequency of DRB1 0405 in patients with AIH versus healthy controls (21.9% vs 6.3%, P=0.04, but P(c) =0.08).
|
11819862 |
2001 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
CD4 T cells from patients with type 2 AIH positive for the predisposing HLA allele DRB1*0701 recognize seven regions of CYP2D6, five of which are also recognized by CD8 T cells.
|
18528928 |
2008 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The genetic AIH risk factor HLA DRB1*03:01 was more frequent in younger patients, and DRB1*04:01 was more frequent in middle-aged patients without an obvious link to virus seropositivities.
|
30487523 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
In 32 patients and 48 healthy controls, polymerase chain reaction amplified with sequence-specific primers (PCR-SSP) was performed to elucidate the relevance of certain alleles or polymorphic sequences of HLA-DRB1 with autoimmune hepatitis.
|
12519226 |
2003 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype.
|
7860360 |
1994 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54-DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis.
|
11984513 |
2002 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The C allele of rs7708392 was associated with AIH, especially AIH without DRB1*04:05, an already established risk factor.
|
29559739 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Two types of autoimmune hepatitis are justified by serological markers, but they also have distinctive genetic associations (DRB1 and DQB1 genes) and autoantigens.
|
25999246 |
2015 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls.
|
15683420 |
2005 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The detailed internal replication and parallel analyses allowed the observation of two of eight AIH cases carrying a rare allele genotype for a previously described AIH-associated gene (FTCD), plus multiple occurrences of known HLA-DRB1 alleles associated with AIH (HLA-DRB1-03:01:01, 13:01:01 and 7:01:01).
|
29995946 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Susceptibility for type 1 autoimmune hepatitis has been associated with the major histocompatibility alleles DRB1*0301, DRB3*0101, DRB1*0401, and DRB4*0103, whereas the DRB1*1501 allele may protect from the disease.
|
9021941 |
1997 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11%, P = 1.2×10(-10); odds ratio [OR] = 3.51) and correlated with elevated serum IgG (3042 vs. 2606 mg/dL, P = 0.041) and anti-smooth muscle antigen positivity (77% vs. 34%, P = 0.000006).
|
24956105 |
2014 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The presence of HLA alleles B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 and possibly A*01:01 enhances the risk of AIH (type 1) in Spanish patients.
|
27206238 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Comparison of DRB1*13- and DRB1*03-positive subjects revealed that the former alleles conferred susceptibility to younger patients with AIH type 1.
|
10406258 |
1999 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined.
|
17020818 |
2007 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that the HLA-DRB1*04:05 allele (P < 0.001, OR = 4.61) and rs9277534 (P = 0.004, OR = 1.67) were independently associated with AIH susceptibility. rs9277534G in the HLA-DP gene is an eQTL that affects gene expression and may contribute to AIH susceptibility.
|
30093645 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of deleterious alleles in TNFAIP3 was higher in the AIH subset without the DRB1 risk alleles than that with (P = 0.0052, OR 5.10, 95%CI 1.55-16.74).
|
31138864 |
2019 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Genetic susceptibility to autoimmune hepatitis is strongly associated with HLA-DRB1 alleles.
|
20933106 |
2011 |