|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the DR4-specific sequence (Val 11 and His 13 at amino acid positions 11 and 13, respectively), but not particular Dw-associated DR4 sequence, in the first domain of the DRB1 chain contributes to susceptibility to autoimmune hepatitis among Japanese.
|
1350267 |
1992 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls.
|
1354193 |
1992 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype.
|
7860360 |
1994 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
These data provide evidence that specific residues in the DR beta polypeptides predispose to autoimmune hepatitis in white patients and genes linked to DRB3*0101 and DRB1*0401 may determine two clinically distinct disease patterns.
|
8119685 |
1994 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Susceptibility for type 1 autoimmune hepatitis has been associated with the major histocompatibility alleles DRB1*0301, DRB3*0101, DRB1*0401, and DRB4*0103, whereas the DRB1*1501 allele may protect from the disease.
|
9021941 |
1997 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
DRB1*0301 and DRB1*0401 are confirmed as the principal susceptibility alleles for type 1 autoimmune hepatitis, and these data support the hypothesis that a lysine residue at position 71 of the DR beta-polypeptide chain may be the major risk factor.
|
9178696 |
1997 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The present findings suggest that the gene or genes conferring susceptibility to AIH lie in the region centromeric to the HLA A locus between HLA C and DRB1.
|
9328330 |
1997 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
American patients with type 1 autoimmune hepatitis had DRB1*03 alleles more commonly than the German patients with type 2 disease (51% vs 17%, p = 0.03) and DRB1*0301 occurred more frequently in the type 1 patients (51% vs 17%, p = 0.03).
|
9399751 |
1997 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
A significant association of autoimmune hepatitis with DRB1*0404 was found, (chi2Y=19.95, pc=0.002, RR=7.71), suggesting the presence of a susceptibility gene located at the DRB1 locus.
|
9672174 |
1998 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Comparison of DRB1*13- and DRB1*03-positive subjects revealed that the former alleles conferred susceptibility to younger patients with AIH type 1.
|
10406258 |
1999 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
We report on a 55-year-old woman in whom AIH developed during the convalescence period of serologically proven acute viral hepatitis type A. HLA class II DRB1*0401, which was reported to be associated with AIH with a moderate coarse and late appearance in life, was found in this patient.
|
10548341 |
1999 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
This study therefore reveals that different HLA-DRB1 allotypes confer susceptibility to AH in children and adults and raises the possibility that PAH and AAH may be triggered by different factors.
|
10573514 |
1999 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1*0301 and DRB1*0401.
|
10613727 |
2000 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
The principal HLA alleles associated with type 1 autoimmune hepatitis in Britain and North America are DRB1*0301 and DRB1*0401.
|
10807521 |
2000 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Our data indicate that susceptibility to AIH remains primarily linked to the HLA-DRB1 locus, and suggest that the association of AIH with TNFA*2 previously observed in whites might be secondary to a linkage disequilibrium with HLA-DRB1*0301.
|
11495038 |
2001 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
In subtypes of DR4, there was a trend of increase in the gene frequency of DRB1 0405 in patients with AIH versus healthy controls (21.9% vs 6.3%, P=0.04, but P(c) =0.08).
|
11819862 |
2001 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54-DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis.
|
11984513 |
2002 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Studies of type 1 AIH have focused on the major histocompatibility complex (MHC), mapping susceptibility to the DRB1 region.
|
12447707 |
2002 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
In 32 patients and 48 healthy controls, polymerase chain reaction amplified with sequence-specific primers (PCR-SSP) was performed to elucidate the relevance of certain alleles or polymorphic sequences of HLA-DRB1 with autoimmune hepatitis.
|
12519226 |
2003 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1 gene is the major genetic determinant in HLA class II region for children with type 1 AIH.
|
15158329 |
2004 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls.
|
15683420 |
2005 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
The most influential gene on type 1 AIH pathogenesis in Japanese is the HLA-DRB1.
|
15763345 |
2005 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined.
|
17020818 |
2007 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
HLA DRB1*03-DRB1*04 is a risk factor for type-1 autoimmune hepatitis, and its impact on outcome relates to the diversity of DRB1*04 alleles that encode a critical motif.
|
17105585 |
2006 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
In conclusion, HLA DRB1*13 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.
|
17510796 |
2008 |