|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
DRB1*03:01 was singly associated with AIH among whites (odds ratio [OR]: 3.09, P = 0.002) and carriers of DRB1*03:01 also carried DQA*05:01 and DQB1*02:01.
|
31211758 |
2019 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
In conclusion, our study does not support the association of HLA-DRB1*04:04:01 with the susceptibility to AIH in Mexican population.
|
31570816 |
2019 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of deleterious alleles in TNFAIP3 was higher in the AIH subset without the DRB1 risk alleles than that with (P = 0.0052, OR 5.10, 95%CI 1.55-16.74).
|
31138864 |
2019 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The genetic AIH risk factor HLA DRB1*03:01 was more frequent in younger patients, and DRB1*04:01 was more frequent in middle-aged patients without an obvious link to virus seropositivities.
|
30487523 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The C allele of rs7708392 was associated with AIH, especially AIH without DRB1*04:05, an already established risk factor.
|
29559739 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The detailed internal replication and parallel analyses allowed the observation of two of eight AIH cases carrying a rare allele genotype for a previously described AIH-associated gene (FTCD), plus multiple occurrences of known HLA-DRB1 alleles associated with AIH (HLA-DRB1-03:01:01, 13:01:01 and 7:01:01).
|
29995946 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that the HLA-DRB1*04:05 allele (P < 0.001, OR = 4.61) and rs9277534 (P = 0.004, OR = 1.67) were independently associated with AIH susceptibility. rs9277534G in the HLA-DP gene is an eQTL that affects gene expression and may contribute to AIH susceptibility.
|
30093645 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
According to the univariate analysis, overlapping features of autoimmune hepatitis (rPSC in 5/5, <i>P</i> ≤ 0.05) and <i>HLA-DRB1*07</i> in the donor (rPSC in 10/15, <i>P</i> ≤ 0.05) represent other potential risk factors for rPSC, while the <i>HLA-DRB1*04</i> (rPSC in 0/6, <i>P</i> ≤ 0.05), <i>HLA-DQB1*03</i> (rPSC in 1/11, <i>P</i> ≤ 0.05), and <i>HLA-DQB1*07</i> (rPSC in 0/7, <i>P</i> ≤ 0.05) recipient alleles may have protective roles.
|
30487703 |
2018 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
The predisposing association of DRB1*04:01 (P = 0.0006, corrected P [Pc] = 0.0193, odds ratio [OR] 2.97, 95% confidence interval [CI] 1.62-5.43), DRB1*04:05 (P = 1.89×10-21, Pc = 5.86×10-20, OR 3.41, 95% CI 2.65-4.38), and DQB1*04:01 (P = 4.66×10-18, Pc = 6.99×10-17, OR 3.89, 95% CI 2.84-5.33) and the protective association of DRB1*13:02 (P = 0.0003, Pc = 0.0080, OR 0.48, 95% CI 0.32-0.72) with Japanese type 1 AIH were observed.
|
29088299 |
2017 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Also the role of HLA-DRB1 genotype has not been evaluated, though it's associated with fibrosis in autoimmune hepatitis.
|
27333038 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the HLA-DRB1*0403 allele differed among Japanese patients with AIH according to the presence or absence of anti-gAChR antibodies.
|
26807576 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles of 76 children with pAILD (autoimmune hepatitis [AIH], autoimmune sclerosing cholangitis [AISC], primary sclerosing cholangitis [PSC]) and of 50 healthy blood donors as control group were analyzed retrospectively.
|
26567543 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The presence of HLA alleles B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 and possibly A*01:01 enhances the risk of AIH (type 1) in Spanish patients.
|
27206238 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
However, DRB1(∗)11 was less frequent in AIH patients.
|
26780502 |
2016 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1.
|
26693492 |
2015 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Two types of autoimmune hepatitis are justified by serological markers, but they also have distinctive genetic associations (DRB1 and DQB1 genes) and autoantigens.
|
25999246 |
2015 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the HLA-DRB1*03:01 and HLA-DRB1*04:01 alleles are both independently associated with the aggregate diagnostic IAIHG score in type-1 AIH patients, but are not essential for AIH development.
|
25611558 |
2015 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11%, P = 1.2×10(-10); odds ratio [OR] = 3.51) and correlated with elevated serum IgG (3042 vs. 2606 mg/dL, P = 0.041) and anti-smooth muscle antigen positivity (77% vs. 34%, P = 0.000006).
|
24956105 |
2014 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
HLA alleles appear to influence the exact phenotype-the most interesting apparent association being between HLA-DRB1*0301-DQB1*0201, liver-kidney microsome autoantibodies (anti-CYP1A2), and autoimmune hepatitis.
|
22344197 |
2012 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis.
|
20957499 |
2011 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
Genetic susceptibility to autoimmune hepatitis is strongly associated with HLA-DRB1 alleles.
|
20933106 |
2011 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
On the other hand, frequencies of A32 and DRB1*04 were high among patients with unclassified autoimmune hepatitis.
|
21480110 |
2011 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*12 was significantly more frequent in AIH patients with positive Hepatitis A IgM than in patients with negative hepatitis A IgM.
|
21067577 |
2010 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
Biomarker |
BEFREE |
Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes.
|
22797478 |
2010 |
|
HLA-DRB1
|
Autoimmune hepatitis
|
0.100 |
GeneticVariation |
BEFREE |
CD4 T cells from patients with type 2 AIH positive for the predisposing HLA allele DRB1*0701 recognize seven regions of CYP2D6, five of which are also recognized by CD8 T cells.
|
18528928 |
2008 |